diff --git a/packages/typespec-ts/src/transform/transformParameters.ts b/packages/typespec-ts/src/transform/transformParameters.ts
index b70e415b43..87464f8ec9 100644
--- a/packages/typespec-ts/src/transform/transformParameters.ts
+++ b/packages/typespec-ts/src/transform/transformParameters.ts
@@ -36,7 +36,8 @@ import {
   getSchemaForType,
   getTypeName,
   isArrayType,
-  isBodyRequired
+  isBodyRequired,
+  isByteOrByteUnion
 } from "../utils/modelUtils.js";
 import {
   getOperationGroupName,
@@ -302,7 +303,18 @@ function transformRequestBody(
   importedModels: Set<string>,
   headers: ParameterMetadata[]
 ) {
-  const contentTypes = extractMediaTypes(parameters.body?.contentTypes ?? []);
+  const rawContentTypes = parameters.body?.contentTypes ?? [];
+  let contentTypes = extractMediaTypes(rawContentTypes);
+
+  // Treat */* as binary when the body is a bytes type
+  if (
+    rawContentTypes.some((ct) => ct === "*/*") &&
+    isByteOrByteUnion(dpgContext, bodyType) &&
+    !contentTypes.includes(KnownMediaType.Binary)
+  ) {
+    contentTypes = [...contentTypes, KnownMediaType.Binary];
+  }
+
   const schema = getSchemaForType(dpgContext, bodyType, {
     mediaTypes: contentTypes,
     isRequestBody: true,
diff --git a/packages/typespec-ts/src/utils/operationUtil.ts b/packages/typespec-ts/src/utils/operationUtil.ts
index 3ad9903b1d..b8dcef18ca 100644
--- a/packages/typespec-ts/src/utils/operationUtil.ts
+++ b/packages/typespec-ts/src/utils/operationUtil.ts
@@ -195,11 +195,19 @@ export function isBinaryPayload(
   body: Type,
   contentType: string | string[]
 ) {
-  const knownMediaTypes: KnownMediaType[] = (
-    Array.isArray(contentType) ? contentType : [contentType]
-  ).map((ct) => knownMediaType(ct));
+  const contentTypes = Array.isArray(contentType) ? contentType : [contentType];
+  const isBytes = body ? isByteOrByteUnion(dpgContext, body) : false;
+
+  // Treat */* as binary when the body is a bytes type
+  if (contentTypes.some((ct) => ct === "*/*") && isBytes) {
+    return true;
+  }
+
+  const knownMediaTypes: KnownMediaType[] = contentTypes.map((ct) =>
+    knownMediaType(ct)
+  );
   for (const type of knownMediaTypes) {
-    if (type === KnownMediaType.Binary && isByteOrByteUnion(dpgContext, body)) {
+    if (type === KnownMediaType.Binary || isBytes) {
       return true;
     }
   }
diff --git a/packages/typespec-ts/test/modularUnit/scenarios/operations/bodyParam/bytesWithWildcardContentType.md b/packages/typespec-ts/test/modularUnit/scenarios/operations/bodyParam/bytesWithWildcardContentType.md
new file mode 100644
index 0000000000..43be23f6ed
--- /dev/null
+++ b/packages/typespec-ts/test/modularUnit/scenarios/operations/bodyParam/bytesWithWildcardContentType.md
@@ -0,0 +1,63 @@
+# bytes response with */* content type should be treated as binary
+
+When a response has `*/*` content type and a `bytes` body, `isBinaryPayload` should return
+`true` so the response is deserialized as `Uint8Array` (binary) rather than `string` (base64).
+
+## TypeSpec
+
+```tsp
+@post op uploadFile(
+  @body body: string
+): {
+  @header contentType: "*/*",
+  @body body: bytes
+};
+```
+
+## Operations
+
+```ts operations
+import { TestingContext as Client } from "./index.js";
+import { getBinaryResponse } from "../static-helpers/serialization/get-binary-response.js";
+import { UploadFileOptionalParams } from "./options.js";
+import {
+  StreamableMethod,
+  PathUncheckedResponse,
+  createRestError,
+  operationOptionsToRequestParameters,
+} from "@azure-rest/core-client";
+
+export function _uploadFileSend(
+  context: Client,
+  body: string,
+  options: UploadFileOptionalParams = { requestOptions: {} },
+): StreamableMethod {
+  return context
+    .path("/")
+    .post({
+      ...operationOptionsToRequestParameters(options),
+      contentType: "text/plain",
+      headers: { accept: "*/*", ...options.requestOptions?.headers },
+      body: body,
+    });
+}
+
+export async function _uploadFileDeserialize(result: PathUncheckedResponse): Promise<Uint8Array> {
+  const expectedStatuses = ["200"];
+  if (!expectedStatuses.includes(result.status)) {
+    throw createRestError(result);
+  }
+
+  return result.body;
+}
+
+export async function uploadFile(
+  context: Client,
+  body: string,
+  options: UploadFileOptionalParams = { requestOptions: {} },
+): Promise<Uint8Array> {
+  const streamableMethod = _uploadFileSend(context, body, options);
+  const result = await getBinaryResponse(streamableMethod);
+  return _uploadFileDeserialize(result);
+}
+```
diff --git a/packages/typespec-ts/test/unit/responsesGenerator.spec.ts b/packages/typespec-ts/test/unit/responsesGenerator.spec.ts
index fd84d19fa9..7be19e8112 100644
--- a/packages/typespec-ts/test/unit/responsesGenerator.spec.ts
+++ b/packages/typespec-ts/test/unit/responsesGenerator.spec.ts
@@ -214,7 +214,7 @@ describe("Responses.ts", () => {
       `
       );
     });
-    it("@header contentType text/plain should keep format to byte(finally string)", async () => {
+    it("@header contentType text/plain with bytes body should be treated as binary", async () => {
       const responses = await emitResponsesFromTypeSpec(`
       @get op read(): {@header contentType: "text/plain", @body body: bytes};
       `);
@@ -232,7 +232,8 @@ describe("Responses.ts", () => {
        /** The request has succeeded. */
        export interface Read200Response extends HttpResponse {
          status: "200";
-         body: string;
+         /** Value may contain any sequence of octets */
+         body: Uint8Array;
          headers: RawHttpHeaders & Read200Headers;
        }
       `