diff --git a/lib/postgrex/protocol.ex b/lib/postgrex/protocol.ex
index 10cc76cd..64c0ce4e 100644
--- a/lib/postgrex/protocol.ex
+++ b/lib/postgrex/protocol.ex
@@ -1363,6 +1363,11 @@ defmodule Postgrex.Protocol do
         err = Postgrex.Error.exception(postgres: fields)
         error_ready(s, status, err, buffer)
 
+      {:ok, msg, buffer} ->
+        status = new_status([], mode: :transaction)
+        s = handle_msg(s, status, msg)
+        recv_streaming(s, buffer)
+
       {:disconnect, _, _} = dis ->
         dis
     end
diff --git a/test/protocol_test.exs b/test/protocol_test.exs
new file mode 100644
index 00000000..d6ba8c23
--- /dev/null
+++ b/test/protocol_test.exs
@@ -0,0 +1,40 @@
+defmodule Postgrex.ProtocolTest do
+  use ExUnit.Case, async: true
+
+  alias Postgrex.Protocol
+
+  defmodule Socket do
+    def send(pid, data) do
+      Kernel.send(pid, {:sent, IO.iodata_to_binary(data)})
+      :ok
+    end
+  end
+
+  test "streaming startup handles asynchronous messages before the copy response" do
+    responses =
+      IO.iodata_to_binary([
+        backend_message(?S, ["application_name", 0, "postgrex", 0]),
+        backend_message(?N, [?S, "NOTICE", 0, ?M, "replication starting", 0, 0]),
+        backend_message(?A, [<<123::32>>, "events", 0, "ready", 0]),
+        backend_message(?W, <<0, 0::16>>)
+      ])
+
+    state = %Protocol{
+      sock: {Socket, self()},
+      buffer: responses,
+      parameters: %{},
+      messages: []
+    }
+
+    assert {:ok, state} = Protocol.handle_streaming("START_REPLICATION", state)
+    assert state.parameters["application_name"] == "postgrex"
+    assert [%{message: "replication starting", severity: "NOTICE"}] = state.messages
+    assert state.buffer == ""
+
+    assert_receive {:sent, <<?Q, _size::32, "START_REPLICATION", 0>>}
+  end
+
+  defp backend_message(type, data) do
+    [type, <<IO.iodata_length(data) + 4::32>>, data]
+  end
+end