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SSLError: [ASN1: NOT_ENOUGH_DATA] when calling dc.op.progeny() on Windows #342
Description
Hello,
When I try to call dc.op.progeny(organism="human") it raises an SSLError on Windows.
Example
import decoupler as dc
progeny = dc.op.progeny(organism="human")
File .../decoupler/op/_progeny.py:68, in progeny(...)
p = resource(name="PROGENy", ...)
File .../decoupler/op/_resource.py:79, in resource(...)
names = set(show_resources()["name"])
File .../decoupler/op/_resource.py:30, in show_resources()
ann = pd.read_csv("https://omnipathdb.org/queries/annotations", sep="\t")
...
File .../ssl.py:584, in SSLContext._load_windows_store_certs(self, storename, purpose)
self.load_verify_locations(cadata=certs)
SSLError: [ASN1: NOT_ENOUGH_DATA] not enough data (_ssl.c:4030)`
Activity
deeenes commentedon Jul 10, 2026
Hello @asif7adil, see this: openssl/openssl#31427 (comment) - reverting or pinning OpenSSL might help. First I thought this is the same truncated TCP stream error which was common ~2 years ago, but this is a different one, it's a breaking change in OpenSSL, they changed the error code it raises after reading the last certificate from the store (signaling end of reading loop). It means Python should fix it, and a Python version without the fix is not compatible with OpenSSL >= 3.6.3. Here is the bug report in the CPython repo. Btw it's crazy that they put this breaking change in a security patch and then they backport it to several earlier versions: this will break things en masse.